Puerarin Ameliorates Experimental Alcoholic Liver Injury by Inhibition of Endotoxin Gut-leakage, Kupffer Cell Activation and Lipopolysaccharide Receptors Expression
نویسندگان
چکیده
Institute of Liver diseases, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China (J.P., T.C., F. H., L.C., Y. Z., L.X., L.X., Q.F., Y.H.); Key Laboratory of Liver and Kidney Diseases in Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, China (J.P., T.C., F. H., L.C., Y. Z., L.X., L.X., Q.F., Y.H.) Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China (J.P. and Y.H.) E-Institute of TCM Internal Medicine, Shanghai Municipal Education Commission, Shanghai, China (Y.H.); JPET Fast Forward. Published on December 31, 2012 as DOI:10.1124/jpet.112.201137
منابع مشابه
Puerarin ameliorates experimental alcoholic liver injury by inhibition of endotoxin gut leakage, Kupffer cell activation, and endotoxin receptors expression.
Puerarin, an isoflavone component extracted from Kudzu (Pueraria lobata), has been demonstrated to alleviate alcohol-related disorders. Our study examined whether puerarin ameliorates chronic alcoholic liver injury through inhibition of endotoxin gut leakage, the subsequent Kupffer cell activation, and endotoxin receptors expression. Rats were provided with the Liber-DeCarli liquid diet for 8 w...
متن کاملPuerarin Ameliorates Experimental Alcoholic Liver Injury by Inhibition of Endotoxin Gut Leakage, Kupffer Cell Activation, and Endotoxin Receptors Expression s
Puerarin, an isoflavone component extracted from Kudzu (Pueraria lobata), has been demonstrated to alleviate alcoholrelated disorders. Our study examined whether puerarin ameliorates chronic alcoholic liver injury through inhibition of endotoxin gut leakage, the subsequent Kupffer cell activation, and endotoxin receptors expression. Rats were provided with the Liber-DeCarli liquid diet for 8 we...
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Kudzu (Pueraria lobata) is one of the earliest medicinal plants used to treat alcohol abuse in traditional Chinese medicine for more than a millennium. However, little is known about its effects on chronic alcoholic liver injury. Therefore, the present study observed the effects of puerariae radix extract (RPE) on chronic alcoholic liver injury as well as Kupffer cells (KCs) activation to relea...
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This review showed the common pathogenic mechanism in the development of non-alcoholic or alcoholic steatohepatitis. In particular, we describe the role of innate immune system and oxidative stress caused by gut-derived endotoxin. Gut-derived endotoxin plays an important role in alcoholic liver injury. It was reported that acute ethanol administration reduced activation of Kupffer cells. It is ...
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